The International Research Foundation for RSD / CRPS has been tracking the changes in facial appearances following treatment with high-dose ketamine. The links below expose a broad spectrum of possible outcomes.

It is believed that the swelling sometimes associated with RSD / CRPS (including in the face) is due to neurogenic inflammation.  

Neurogenic inflammation is a general term used to describe the local release of inflammatory mediators from afferent neurons such as substance P and calcitonin gene-related peptide.


Changes in facial appearance before and after the 3 day ketamine infusion. 

Click on the names below to learn more.


10. Cynthia
12. John
5. Laurel
13. Mark
6. Robert
14. Cheryl
7. Leslie
15. Melinda
8. Joann

9. Sandra


The 3-day or 4-day high-dose ketamine treatments are performed on an outpatient basis at the Foundation ’s Surgical Center. The patient has the option of having the IV left in place throughout the treatment.

At our Surgical Center every effort is made to document outcome on an objective basis. Videos and pain thresholds document the effectiveness of the treatment. Patients are provided this outcome material (including videos) for their record. The baseline video is performed on a Monday with the post-treatment video performed the day following the last ketamine infusion. Pain thresholds are performed before and after each infusion. Families generally stay in Tampa, Florida USA for one week for the treatment.

For more information about our Surgery Center dedicated to the treatment of RSD / CRPS, please visit:

The RSD / CRPS Treatment Center & Research Institute